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Qiagen
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Human Protein Atlas
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10X Genomics
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Qiagen
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Illumina Inc
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Proteintech
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Allen Institute for Brain Science
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Proteintech
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Allen Institute for Brain Science
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Norgen Biotek
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BioChain Institute
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Image Search Results
Journal: Cell reports methods
Article Title: Precise detection of cell-type-specific domains in spatial transcriptomics.
doi: 10.1016/j.crmeth.2024.100841
Figure Lengend Snippet: Figure 2. De-spot identified similar cell-type-specific domains in multiple mouse brain slices (A) Free frozen tissue (slice 1) and FFPE tissue (slice 2). Annotations of anatomic mouse brain structure are from the Allen Brain Atlas. (B) Previously published single-cell profiles, including seven annotated cell types: astrocytes-ependymal, endothelial-mural, interneurons, microglia, oligo- dendrocytes, pyramidal CA1, and pyramidal SS. (C) 3D Landscapes of slice 1 and slice 2 generated by Giotto. The color of each domain corresponds to the cell types with the same color in (B). (D) 3D Landscapes of slice 1 and slice 2 generated by Seurat. (E) 3D Landscapes of slice 1 and slice 2 generated by CARD.
Article Snippet: REAGENT or RESOURCE SOURCE IDENTIFIER Deposited data scRNA-seq data of mouse brain cortex Zeisel et al.39 GEO: GSE60361 10x Visium data of mouse brain cortex (free frozen) 10x Genomics https://www.10xgenomics.com/resources/ datasets/mouse-brain-section-coronal-1standard-1-0-0 10x Visium data of
Techniques: Generated
Journal: Cell reports methods
Article Title: Precise detection of cell-type-specific domains in spatial transcriptomics.
doi: 10.1016/j.crmeth.2024.100841
Figure Lengend Snippet: Figure 3. De-spot detected co-localized cell-type-specific domains using multiple profiles (A) FFPE tissue of the mouse kidney. The slice is histologically annotated to the renal cortex, renal medulla 1, renal medulla 2, and pelvis. (B) Previously published mouse kidney profiles generated by scRNA-seq and small nuclear RNA sequencing, containing 13 cell types annotated by Wu et al.47 CD-PC, collecting duct principal cells; CNT, connecting tubule; DCT, distal convoluted tubules; EC, endothelial cells; IC, intercalated cells; LHAL, the loop of Henle ascending loop; LHDL, the loop of Henle descending loop; MC, mesangial cells; MØ, macrophages; PT, proximal tubules; Pod, po- docytes.
Article Snippet: REAGENT or RESOURCE SOURCE IDENTIFIER Deposited data scRNA-seq data of mouse brain cortex Zeisel et al.39 GEO: GSE60361 10x Visium data of mouse brain cortex (free frozen) 10x Genomics https://www.10xgenomics.com/resources/ datasets/mouse-brain-section-coronal-1standard-1-0-0 10x Visium data of
Techniques: Generated, RNA Sequencing
Journal: bioRxiv
Article Title: TAF15 amyloids propagate via defined motifs in a prion-like fashion
doi: 10.1101/2025.11.17.688886
Figure Lengend Snippet: (A) Electron micrographs of recombinant tau(287–391), α-synuclein, and Aβ 42 fibrils used as heterologous amyloid controls. (B) TAF15 biosensor FRET readout shows no induction by heterologous amyloids (tau, α-synuclein, Aβ 42 ) relative to TAF15 seeds, confirming molecular specificity. Statistics: Two-way ANOVA with t-tests for multiple comparison (n=4 individual replicates). Dotted line indicates control averages (untreated cells). (C-D) aFTLD-U brain lysates (n=4 individual replicates) seed the TAF15 biosensor in a concentration-dependent manner, demonstrating prion-like propagation of ex vivo TAF15 aggregates. Dotted line indicates control averages (untreated cells). (E) TEM validation of recombinant FUS fibrils displaying canonical amyloid morphology. (F) FRET quantification in the TAF15 biosensor demonstrating absence of cross-seeding by FUS aggregates (n=4 individual replicates). (G) Confocal micrographs of biosensor cells co-expressing mRuby-tagged FUS and seeded with TAF15 aggregates, showing co-localization of FUS within TAF15 inclusions.
Article Snippet: All individuals selected for this study exhibited neuronal cytoplasmic inclusions and occasional vermiform neuronal intranuclear inclusions in the dentate gyrus and frontal cortex that were immunoreactive for
Techniques: Recombinant, Comparison, Control, Concentration Assay, Ex Vivo, Biomarker Discovery, Expressing
Journal: STAR Protocols
Article Title: A protocol to extract cell-type-specific signatures from differentially expressed genes in bulk-tissue RNA-seq
doi: 10.1016/j.xpro.2022.101121
Figure Lengend Snippet:
Article Snippet:
Techniques: Gene Expression, Software